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Etifoxine

CAT: 0804-HY-16579A-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-16579A-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Etifoxine, a non-benzodiazepine GABAergic compound, is a positive allosteric modulator of α1β2γ2 and α1β3γ2 subunit-containing GABAA receptors. Etifoxine reveals anxiolytic and anticonvulsant properties in rodents[1][2][3].
CAS Number
21715-46-8
Product Name Alternative
HOE 36-801
UNSPSC
12352005
Hazard Statement
H302, H401
Target
GABA Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/etifoxine.html
Purity
99.27
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
ClC1=CC=C2C(C(C3=CC=CC=C3)(C)OC(NCC)=N2)=C1
Molecular Formula
C17H17ClN2O
Molecular Weight
300.78
Precautions
H302, H401
References & Citations
[1]Marc Verleye, et al. Effects of etifoxine on ligand binding to GABA (A) receptors in rodents. Neurosci Res. 2002 Oct;44 (2) :167-72.|[2]Alain Hamon, et al. The modulatory effects of the anxiolytic etifoxine on GABA (A) receptors are mediated by the beta subunit. Neuropharmacology. 2003 Sep;45 (3) :293-303.|[3]Marc Verleye, et al. Differential effects of etifoxine on anxiety-like behaviour and convulsions in BALB/cByJ and C57BL/6J mice: any relation to overexpression of central GABAA receptor beta2 subunits? Eur Neuropsychopharmacol. 2011 Jun;21 (6) :457-70.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Citation 01
Psychopharmacology (Berl) . 2025 Jun;242 (6) :1303-1319.|Front Mol Neurosci. 2022 May 24:15:850904.|Glasgow Caledonian University. 2025.

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