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Tafamidis

CAT: 0400-SIH-584-5MGSize: 5 mgDry Ice: NoHazardous: No
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CAT#:0400-SIH-584-5MGSize:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Tafamidis functions as a chaperone that stabilizes the correctly folded tetrameric form of the transthyretin (TTR) protein by binding in one of the two thyroxine-binding sites of the tetramer (1). In drug form, it is used to delay impairment of peripheral nerve function in adults with familial amyloid polyneuropathy.
Description
Transthyretin Dissociation Inhibitor
CAS Number
594839-88-0
Product Name Alternative
2- (3,5-Dichlorophenyl) -1,3-Benzoxazole-6-Carboxylic Acid, FX-1006, 2- (3,5-Dichlorophenyl) -6-benzoxazole carboxylic acid
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Alzheimer's Disease | Axon Markers | Cell Markers | Cell Signaling | Cytoskeleton | Microtubules | MT Associated Proteins | Neurodegeneration | Neuron Markers | Neuroscience | Tangles & Tau
Purity
>98% (TLC) ; NMR (Conforms)
Weight
0.005
Format
Off-white powder
Solubility
May be dissolved in DMSO (25 mg/ml, warm)
Molecular Formula
C14H7Cl2NO3
Molecular Weight
308.1
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Said G, Grippon S, Kirkpatrick P. (2012). Nature Reviews. Drug Discovery. 11(3): 185–186.

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CatalogName
BA8568-100Tafamidis

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