Tafamidis-d3

CAT: 0931-TMIH-0549-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0931-TMIH-0549-01Size:1 mg
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Bioactivity
Tafamidis-d3 is a deuterated compound of Tafamidis. Tafamidis has a CAS number of 594839-88-0. Tafamidis is a kinetic stabilizer of transthyretin (TTR) that prevents amyloidogenesis by wild-type and mutant TTRs. It binds to TTR with negative cooperativity (Kd1: 3 nM; Kd2: 278 nM) to stabilize the TTR dimer-dimer interface and inhibit tetrameric dissociation. Tafamidis stabilizes wild-type and clinically significant V30M and V122I mutant TTR amyloidogenic homotetramers (EC50s: 2.7-3.2 ?M) under fibril-promoting, denaturing, and physiological conditions in vitro. It stabilizes TTR heterotetramers containing wild-type and mutant subunits ex vivo in human plasma derived from patients carrying V30M or V1221 mutations when used at a concentration of 7.2 ?M. Formulations containing tafamidis have been used for the treatment of familial amyloid polyneuropathy.
Smiles
O=C(C1=C([2H])C([2H])=C2N=C(C3=CC(Cl)=CC(Cl)=C3)OC2=C1[2H])O
Molecular Formula
C14H4D3Cl2NO3
Molecular Weight
311.14
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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