Tolcapone

• Background:

  Catechol O-methyltransferase inhibitor (COMT), inhibiting both brain and peripheral enzymes1. Potent inhibitor of alpha-synuclein and beta-amyloid oligomerization and fibrillogenesis protecting against extracellular toxicity2. Binds to transthyretin (TTR) with high affinity (21 to 58 nM) and inhibits TTR aggregation in human plasma and prevents TTR-induced cytotoxicity in vitro. Stabilizes TTR in mice and humans in vivo3. Inhibits O-methylation of exogenous polyphenols such as EGCG4. Cell permeable.

• Description:

  COMT inhibitor

• Product Name Alternative:

  (3,4-dihydroxy-5-nitrophenyl) - (4-methylphenyl) methanone, Tolcapone, Tasmar, Ro 40-7592

• UNSPSC:

  41116105

• Type:

  Inhibitor

• Source:

  Synthetic

• Field of Research:

  Neuroscience | Neurodegeneration | Parkinson's Disease | Alzheimer's Disease

• Purity:

  >98% (TLC) ; NMR (Conforms)

• Weight:

  0.01

• Format:

  Yellow powder

• Solubility:

  Soluble in DMSO (25 mg/ml), or ethanol (25 mg/ml)

• Molecular Formula:

  C14H11NO5

• Molecular Weight:

  273.2

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. PT Manisto et al. Br. J. Pharmacol. 1992 105:569 2. S Di Giovanni et al. J. Biol. Chem. 2010 285:14941 3. R Sant’Anna et al. Nat. Commun. 2016 7:10787 4. SC Forester and JD Lambert J. Funct. Foods 2015 17:183

• CAS Number:

  134308-13-7