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Tolcapone

CAT: 0400-SIH-540-10MGSize: 10 mgDry Ice: NoHazardous: No
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CAT#:0400-SIH-540-10MGSize:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Catechol O-methyltransferase inhibitor (COMT), inhibiting both brain and peripheral enzymes1. Potent inhibitor of alpha-synuclein and beta-amyloid oligomerization and fibrillogenesis protecting against extracellular toxicity2. Binds to transthyretin (TTR) with high affinity (21 to 58 nM) and inhibits TTR aggregation in human plasma and prevents TTR-induced cytotoxicity in vitro. Stabilizes TTR in mice and humans in vivo3. Inhibits O-methylation of exogenous polyphenols such as EGCG4. Cell permeable.
Description
COMT inhibitor
CAS Number
134308-13-7
Product Name Alternative
(3,4-dihydroxy-5-nitrophenyl) - (4-methylphenyl) methanone, Tolcapone, Tasmar, Ro 40-7592
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Neuroscience | Neurodegeneration | Parkinson's Disease | Alzheimer's Disease
Purity
>98% (TLC) ; NMR (Conforms)
Weight
0.01
Format
Yellow powder
Solubility
Soluble in DMSO (25 mg/ml), or ethanol (25 mg/ml)
Molecular Formula
C14H11NO5
Molecular Weight
273.2
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. PT Manisto et al. Br. J. Pharmacol. 1992 105:569 2. S Di Giovanni et al. J. Biol. Chem. 2010 285:14941 3. R Sant’Anna et al. Nat. Commun. 2016 7:10787 4. SC Forester and JD Lambert J. Funct. Foods 2015 17:183

Alternative Products

CatalogName
TRC-T535250-100MGTolcapone

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