Teprenone

CAT: 0400-SIH-526-50MGSize: 50 mgDry Ice: NoHazardous: No
CAT#:0400-SIH-526-50MGSize:50 mg
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Background
Teprenone can induce expression of HSP70, HSPB8, and HSPB1. Induction of HSP70 expression is protective against the development of various diseases, such as inflammatory bowel disease, hypoxic/ischemic brain injury and spinal and bulbar muscular atrophy (cytoprotective and anti-inflammatory effects) (1, 2). Reports indicate that Teprenone protects against NSAID-induced gastric and intestinal lesions by induction of HSP70 expression (2). Other studies have shown that it induces expression of HSPB8 and HSPB1 and reduces the formation of amyloid oligomers as well as insoluble aggregates in HSPB5 R120G TG mice (3, 4).
Description
HSP70 Inducer
CAS Number
6809-52-5
Product Name Alternative
Geranylgeranylacetone, GGA, 6,10,14,18-Tetramethyl-5,9,13,17-nonadecatetraen-2-one
UNSPSC
41116105
Type
Inducer
Source
Synthetic
Field of Research
Cancer | Heat Shock | Cell Signaling | Neuroscience
Purity
>95% (GC)
Weight
0.05
Format
Colorless Oil
Solubility
Soluble in DMSO (30 mg/ml)
Molecular Formula
C23H38O
Molecular Weight
330.6
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Kobayashi T., Ohta Y., Yoshino J and Nakazawa S. (2001) Pharmacol Res. 43(1): 23-30. 2. Sambroski P., Grzymislawski M. (2015) Adv Clin Med. 24(3): 525-530. 3. Marunouchi T., Inomata S., Sanbe A., Takagi N., Tanonaka K. (2014) Eur J Pharmacol. 730: 1401-47. 4. Sanbe A., et al. (2009) PLoS One. 4(4): e5351.

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