SC 79

• Background:

  SC 79 is an activator of Akt (protein kinase B). Specifically, it has been shown to bind the plecktrin homology (PH) domain of Akt. This mimics the binding of Phosphatidylinositol (3,4,5)-trisphosphates, which induces a conformational change in Akt, that enhances phosphorylation and activation.

• Description:

  Akt kinase activator

• Product Name Alternative:

  SC-79, SC79, 2-Amino-6-chloro-α-cyano-3- (ethoxycarbonyl) -4H-1-benzopyran-4-acetic acid ethyl ester

• UNSPSC:

  41116105

• Type:

  Activator

• Source:

  Synthetic

• Field of Research:

  Cell Signaling

• Purity:

  98% (TLC) ; NMR (Conforms)

• Weight:

  0.025

• Format:

  White solid

• Solubility:

  May be dissolved in DMSO (100mg/mL); or ethanol (40mg/mL, warm)

• Molecular Formula:

  C17H17ClN2O5

• Molecular Weight:

  364.8

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Jo H., et al. (2012) Pro. Nat. Acad. Sci. USA. 109(26): 10581–10586.

• CAS Number:

  305834-79-1