SC 514

• Background:

  SC 514 is a selective and reversible inhibitor of IκB kinase 2 / IKKβ (IKK-2). It has been shown to displays > 10-fold selectivity over 28 other kinases including JNK, p38, MK2 and ERK. SC-514 exhibits anti-inflammatory properties. SC 514 is cell permeable.

• Description:

  IKK-2 kinase inhibitor

• Product Name Alternative:

  4-Amino-[2',3'-bithiophene]-5-carboxamide

• UNSPSC:

  41116105

• Type:

  Inhibitor

• Source:

  Synthetic

• Field of Research:

  Cell Signaling | Cancer | Apoptosis | Cancer Growth Inhibitors | Tyrosine Kinase Inhibitors

• Purity:

  ≥98% (TLC)

• Weight:

  0.01

• Format:

  Yellow solid

• Solubility:

  Soluble in DMSO (>25 mg/ml)

• Molecular Formula:

  C9H8N2OS2

• Molecular Weight:

  224.3

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Kishore N., et al. (2003) J. Biol. Chem. 278(35): 32861–32871. 2. Baxter A., et al. (2004) Bioorganic Med. Chem. Letters. 14(11): 2817–2822.

• CAS Number:

  354812-17-2