BIBW 2992

• Background :

  BIBW 2992 is a potent and irreversible ErbB inhibitor. It has also been shown to inhibit EGFR/Neu.

• Description :

  EGFR, HER2 kinase inhibitor

• Product Name Alternative :

  Afatinib, N-​[4-​[ (3-​chloro-​4-​fluorophenyl) amino]-​7-​[[ (3S) -​tetrahydro-​3-​furanyl]oxy]-​6-​quinazolinyl]-​4-​ (dimethylamino) -​2-​butenamide

• UNSPSC :

  41116105

• Type :

  Inhibitor

• Source :

  Synthetic

• Field of Research :

  Cell Signaling | Cancer | Apoptosis | Cancer Growth Inhibitors | Tyrosine Kinase Inhibitors

• Purity :

  >99%

• Weight :

  0.025

• Format :

  Crystalline solid

• Solubility :

  Soluble in DMSO at 200 mg/ml; in ethanol at 25 mg/ml

• Molecular Formula :

  C24H25ClFN5O3

• Molecular Weight :

  485.9

• Precautions :

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations :

  1. Ioannou, N., et al. (2011) Br. J. Cancer. 105(10): 1554–1562.

• CAS Number :

  850140-72-6