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Auranofin

CAT: 0400-SIH-493-50MGSize: 50 mgDry Ice: NoHazardous: No
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CAT#:0400-SIH-493-50MGSize:50 mg
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Background
Auranofin is derivative of gold and has been widely used as an anti-arthritic drug. It inhibits both leukocyte activation pathways at multiple sites and the release of inflammatory mediators from human macrophages, basophils, and pulmonary mast cells. Auranofin has been shown to inhibit human neutrophil 5-lipoxygenase, thioredoxin reductase (TrxR), IκB kinase (IKK).
Description
IKK kinase inhibitor
CAS Number
34031-32-8
Product Name Alternative
1-Thio-β-D-glucopyranosatotriethylphosphine gold-2,3,4,6-tetraacetate, 3,4,5-Triacetyloxy-6- (acetyloxymethyl) oxane-2-thiolate triethylphosphanium, SKF 39162
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cell Signaling | Cancer | Apoptosis | Cancer Growth Inhibitors | Tyrosine Kinase Inhibitors
Purity
≥98% (HPLC)
Weight
0.05
Format
White solid
Solubility
Soluble in DMSO (5 mg/ml) or 100% ethanol (4 mg/ml)
Molecular Formula
C20H34AuO9PS
Molecular Weight
678.5
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Betts W.H., Hurst N.P., Murphy G.A., & Cleland L.G. (1990) Biochem. Pharm. 39(7). 1233–1237. 2. Rudkowski R., Ziegler J.B., Graham G.G., & Champion G.D. (1991) Biochem. Pharm. 41(12): 1921–1929.

Alternative Products

CatalogName
HY-B1123-01Auranofin

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