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Auranofin (Standard)

CAT: 0804-HY-B1123R-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B1123R-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Auranofin (Standard) is the analytical standard of Auranofin. This product is intended for research and analytical applications. Auranofin (SKF-39162) is a thioredoxin reductase (TrxR) inhibitor with an IC50 of 0.2 μM. Auranofin exhibits antiviral activity against SARS-CoV21, with a CC50 of 4.2 μM for monkey kidney Vero E6 cells.
CAS Number
34031-32-8
UNSPSC
12352100
Target
Bacterial; Reference Standards; SARS-CoV
Related Pathways
Anti-infection; Others
Field of Research
Cancer; Infection; Inflammation/Immunology
Smiles
CC(O[C@@H]([C@@H]([C@H]1COC(C)=O)OC(C)=O)[C@H]([C@@H](O1)[S-][Au+][P](CC)(CC)CC)OC(C)=O)=O
Molecular Formula
C20H34AuO9PS
Molecular Weight
678.48
References & Citations
[1]Cox AG, et al. The thioredoxin reductase inhibitor auranofin triggers apoptosis through a Bax/Bak-dependent process that involves peroxiredoxin 3 oxidation. Biochem Pharmacol. 2008 Oct 30;76 (9) :1097-109.|[2]Park SH, et al. Auranofin displays anticancer activity against ovarian cancer cells through FOXO3 activation independent of p53. Int J Oncol. 2014 Oct;45 (4) :1691-8.|[3]Park N, et al. Auranofin promotes mitochondrial apoptosis by inducing annexin A5 expression and translocation in human prostate cancer cells. J Toxicol Environ Health A. 2014;77 (22-24) :1467-76.|[4]Lee JC, et al. Effect of auranofin treatment on aberrant splenic interleukin production in adjuvant arthritic rats. J Immunol. 1987 Nov 15;139 (10) :3268-74.|[5]Shuofeng Yuan, et al. Metallodrug ranitidine bismuth citrate suppresses SARS-CoV-2 replication and relieves virus-associated pneumonia in Syrian hamsters. Nat Microbiol. 2020 Oct 7.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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