WHI P131

• Background:

  WHI P131 also known as Janex-1, is a reversible, potent, and specific inhibitor of JAK3. WHI P131 is cell permeable. It has been seen to inhibit glioblastoma cell adhesion and migration, as well as, thrombin-induced platelet aggregation.

• Description:

  JAK3 kinase inhibitor

• Product Name Alternative:

  WHI-P131, Janex 1, 4-​[ (6, ​7-​dimethoxy-​4-​quinazolinyl) amino]-​phenol

• UNSPSC:

  41116105

• Type:

  Inhibitor

• Source:

  Synthetic

• Field of Research:

  Cell Signaling | Cancer | Apoptosis | Cancer Growth Inhibitors | Tyrosine Kinase Inhibitors

• Purity:

  ≥98%

• Weight:

  0.05

• Format:

  White to off-white solid

• Solubility:

  Soluble in DMSO (~1 mg/ml), and DMF (~1 mg/ml)

• Molecular Formula:

  C16H15N3O3

• Molecular Weight:

  297.3

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Sudbeck E.A., et al. (1999) Clin. Cancer Res: J. Am. Asso. Cancer Res. 5(6): 1569–1582.

• CAS Number:

  202475-60-3