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NVPBEZ235

CAT: 0400-SIH-465-25MGSize: 25 mgDry Ice: NoHazardous: No
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CAT#:0400-SIH-465-25MGSize:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
NVPBEZ235 is a specific PI 3-kinase (PI3K) tyrosine kinase inhibitor, which shows dual PI3K/mTOR inhibition. NVPBEZ235 has also been shown to inhibit ATR. It has demonstrated antiproliferative activity against tumor cell lines in animal models of cancer.
Description
PI 3-kinase inhibitor
CAS Number
915019-65-7
Product Name Alternative
4-​[2, ​3-​dihydro-​3-​methyl-​2-​oxo-​8-​ (3-​quinolinyl) -​1H-​imidazo[4, ​5-​c]quinolin-​1-​yl]-​α, ​α-​dimethyl-​benzeneacetonitrile
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cell Signaling | Cancer | Apoptosis | Cancer Growth Inhibitors | Tyrosine Kinase Inhibitors
Purity
≥97%
Weight
0.025
Format
Crystalline solid
Solubility
Soluble in chloroform (1 mg/ml), 1-methyl-2-pyrrolidnone (2 mg/ml at 75 °C), DMSO (1.33 mg/ml), and DMF (10 mg/ml at 75 °C)
Molecular Formula
C30H23N5O
Molecular Weight
469.5
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Yasumizu Y., et al. (2014) J. Urology. 191(1): 227–234. 2. Shortt J., et al. (2013) Blood. 121(15): 2964–2974.

Alternative Products

CatalogName
MBS808165-01NVPBEZ235

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