24 (S) -Hydroxycholesterol

• Background:

  Endogenous agonist for the nuclear receptor LXR. Important metabolite of cholesterol in the brain. Displays neurotoxic effects on human neuroblastoma cells. Cerebrospinal fluid concentrations of 24(S)-hydroxycholesterol are increased in patients with Alzheimer's disease and mild cognitive impairment.

• Description:

  LXR ligand

• Product Name Alternative:

  (3β,24S) -Cholest-5-ene-3,24-diol

• UNSPSC:

  41116105

• Type:

  Ligand

• Source:

  Synthetic

• Field of Research:

  Cell Signaling

• Purity:

  >98%

• Weight:

  0.005

• Format:

  White solid

• Solubility:

  Soluble in ethanol (10 mg/ml) or DMSO (10 mg/ml - requires warming up to ~40°C).

• Molecular Formula:

  C27H46O2

• Molecular Weight:

  402.7

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Chawla A., et al. (2001) Science. 294(5548): 1866-70. 2. Lütjohann D., et al. (1996) Proc. Natl. Acad. Sci. USA. 93(18): 9799-804. 3. Kölsch H., et al. (1999) Brain Res. 818(1): 171-5. 4. Schönknecht P., et al. (2002) Neurosci. Lett. 324(1): 83-5. 5. Leoni V., et al. (2006) Neurosci. Lett. 397(1-2): 83-7.

• CAS Number:

  474-73-7