24(S)-Hydroxycholesterol

24(S)-Hydroxycholesterol

• Background: Endogenous agonist for the nuclear receptor LXR. Important metabolite of cholesterol in the brain. Displays neurotoxic effects on human neuroblastoma cells. Cerebrospinal fluid concentrations of 24(S)-hydroxycholesterol are increased in patients with Alzheimer's disease and mild cognitive impairment.
• Description: LXR ligand
• Product Name Alternative: (3β,24S)-Cholest-5-ene-3,24-diol
• CAS Number: 474-73-7
• UNSPSC: 41116105
• Source: Synthetic
• Purity: >98%
• Weight: 0.001
• Format: White solid
• Solubility: Soluble in ethanol (10 mg/ml) or DMSO (10 mg/ml - requires warming up to ~40°C).
• Molecular Formula: C27H46O2
• Molecular Weight: 402.7
• Precautions: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
• References & Citations: 1. Chawla A., et al. (2001) Science. 294(5548): 1866-70. 2. Lütjohann D., et al. (1996) Proc. Natl. Acad. Sci. USA. 93(18): 9799-804. 3. Kölsch H., et al. (1999) Brain Res. 818(1): 171-5. 4. Schönknecht P., et al. (2002) Neurosci. Lett. 324(1): 83-5. 5. Leoni V., et al. (2006) Neurosci. Lett. 397(1-2): 83-7.