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U0126

CAT: 0400-SIH-380-25MGSize: 25 mgDry Ice: NoHazardous: No
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CAT#:0400-SIH-380-25MGSize:25 mg
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Background
U-0126 is a novel, potent and selective MEK inhibitor (MEK1; IC50=72nM, MEK2; IC50=58nM). Inhibits AP-1 transcription activity. Blocks the production of inflammatory cytokines and matrix metalloproteinases. Binding of extracellular growth factors to cell surface receptors often results in activation of the mitogen-activated protein kinase (MAPK). MAPK is regulated by MAPK kinase, also called MEK. Deprivation of growth factors during cell culture or intracellular MEK inhibition leads to inhibition of proliferation and apoptotic cell death. N Blank et al. (2002) have shown that U0126, a common used MEK inhibitor and compound that itself has no intrinsic fluorescence in vitro but develops an intensive fluorescence during cell culture which can be observed in all fluorescence channels with predominance in the FL1 channel (525nm).
Description
MEK inhibitor
CAS Number
109511-58-2
Product Name Alternative
1,4-Diamino-2,3-dicyano-1,4-bis[2-a­minophenylthio]butadiene
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cell Signaling
Purity
>98%
Weight
0.025
Format
White solid
Solubility
Soluble in DMSO (>10 mg/ml), 100% ethanol (2 mg/ml)
Molecular Formula
C18H16N6S2
Molecular Weight
380.5
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Duncia J.V., et a.l (1998) Bioorg. Med. Chem. Lett. 8(20): 2839-44. 2. Favata M.F., et al. (1998) J. Biol. Chem. 273(29): 18623-32. 3. Davies S.P., et al. (2000) Biochem. J. 351(Pt1): 95-105. 4. Namura S., et al. (2001) Proc. Natl. Acad. Sci. U.S.A. 98(20): 11569-74.

Alternative Products

CatalogName
BA2003-10U0126

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