PJ-34

• Background :

  PJ-34 is a selective inhibitor of Poly (ADP-Ribose) polymerase (PARP). Studies have shown that the use of PJ-34 on severe inflammatory diseases, in particular experimental allergic encephalomyelitis (EAE) have contributed to a shift of the immune response from a pro-inflammatory Th1 to anti-inflammatory th2 phenotype (1).

• Description :

  PARP inhibitor

• Product Name Alternative :

  N- (6-Oxo-5,6-dihydrophenanthridin-2-yl) -N, Ndimethylacetamide . HCl

• UNSPSC :

  41116105

• Type :

  Inhibitor

• Source :

  Synthetic

• Field of Research :

  Cancer | Apoptosis | Cancer Growth Inhibitors | PARP Inhibitors

• Purity :

  ≥98% (HPLC) ; NMR (Conforms)

• Weight :

  0.01

• Format :

  White to yellow solid.

• Solubility :

  May be dissolved in DMSO (30 mg/ml) or water (20 mg/ml)

• Molecular Formula :

  C17H17N3O2•HCL•H2O

• Molecular Weight :

  331.8

• Precautions :

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations :

  1. Scott G., Kean R., Mikheeva., Fabis M., Mabley J.J. (2004) The Journal of Pharmacology and Exp. Therapeutics. 310(3): 1053-1061.

• CAS Number :

  344458-15-7