Temozolomide

• Background:

  Temozolomide is a membrane permeable DNA alkylating agent which acts as an anti-tumor and anti-angiogenic agent by alkylating the N-7 or O-6 positions of guanine residues which triggers tumor cell death (1-2). It has been used clinically as an anti-cancer agent (3) and has been found to induce autophagy in a variety of cell lines (4).

• Description:

  AGT inhibitor

• Product Name Alternative:

  3-Methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide; 8-Carbamoyl-3-methylimidazo[5,1-d]-1,2,3,5-tetrazin-4 (3H) -one

• UNSPSC:

  41116105

• Type:

  Inhibitor

• Source:

  Synthetic

• Field of Research:

  Cancer | Apoptosis

• Purity:

  ≥99% (TLC) ; NMR (Conforms)

• Weight:

  0.025

• Format:

  Off white powder

• Solubility:

  Soluble in DMSO (25 mg/ml, warm) or water (weakly)

• Molecular Formula:

  C6H6N6O2

• Molecular Weight:

  194.2

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Kurzen H., et al. (2003) Anticancer Drugs. 14: 515. 2. Gunther W., et al. (2003) Br. J. Cancer. 88: 463. 3. Danson S.J., et al. (2001) Expert Rev. Anticancer Ther. 10: 13. 4. Natsumeda M., et al. (2011) Neuropathology. 31: 486.

• CAS Number:

  85622-93-1