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Vorinostat (SAHA)

CAT: 0400-SIH-359-50MGSize: 50 mgDry Ice: NoHazardous: No
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CAT#:0400-SIH-359-50MGSize:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Potent and selective histone deacetylase inhibitor. Induces apoptosis in a variety of tumor cell lines. Synergizes with kinase inhibitors to kill CNS tumor cells. Cell permeable.
Description
HDAC inhibitor
CAS Number
149647-78-9
Product Name Alternative
Suberoylanilide-hydroxamic acid; Vorinostat; N-Hydroxy-N'-phenyloctanediamide
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cell Signaling | Epigenetics and Nuclear Signaling | Cancer
Purity
>98% (TLC), NMR conforms
Weight
0.05
Format
White Solid
Solubility
Soluble in 50 mg/ml DMSO, or 2 mg/ml Ethanol
Molecular Formula
C14H20N2O3
Molecular Weight
264.3
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Vrana J.A., et al., (1999) Oncogene. 18: 7016. 2. Butler L.M., et al., (2002) Proc. Natl. Acad. Sci. USA. 99: 11700. 3. Tang Y., et al., (2012) Cancer Biol. Ther. 2012 13(7): 567-574.

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