B-AP15

• Background :

  Abrogates the deubiquitinating activity of the 19S regulatory particle by inhibiting ubiquitin C-terminal hydrolase 5 (UCHL5) and ubiquitin-specific peptidase 14 (USP14) resulting in accumulation of polyubiquitin in cells. b-AP15 induces tumor cell apoptosis and tumor progression in four different solid tumor models in vivo.

• Description :

  Deubiquitinase (DUB) Inhibitor (NSC-687852)

• Product Name Alternative :

  (3E,5E) -1-Acryloyl-3,5-bis (4-nitrobenzylidene) -4-piperidinone

• UNSPSC :

  41116105

• Type :

  Inhibitor

• Source :

  Synthetic

• Field of Research :

  Cancer | Apoptosis

• Purity :

  >98%

• Weight :

  0.005

• Format :

  Pale Yellow Solid

• Solubility :

  Soluble in 35 mg/ml DMSO

• Molecular Formula :

  C22H17N3O6

• Molecular Weight :

  419.4

• Precautions :

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations :

  1. D'Arcy P., et al. (2011) Nature Medicine 17: 1636.

• CAS Number :

  1009817-63-3