B-AP15

• Background:

  Abrogates the deubiquitinating activity of the 19S regulatory particle by inhibiting ubiquitin C-terminal hydrolase 5 (UCHL5) and ubiquitin-specific peptidase 14 (USP14) resulting in accumulation of polyubiquitin in cells. b-AP15 induces tumor cell apoptosis and tumor progression in four different solid tumor models in vivo.

• Description:

  Deubiquitinase (DUB) Inhibitor (NSC-687852)

• Product Name Alternative:

  (3E,5E) -1-Acryloyl-3,5-bis (4-nitrobenzylidene) -4-piperidinone

• UNSPSC:

  41116105

• Type:

  Inhibitor

• Source:

  Synthetic

• Field of Research:

  Cancer | Apoptosis

• Purity:

  >98%

• Weight:

  0.005

• Format:

  Pale Yellow Solid

• Solubility:

  Soluble in 35 mg/ml DMSO

• Molecular Formula:

  C22H17N3O6

• Molecular Weight:

  419.4

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. D'Arcy P., et al. (2011) Nature Medicine 17: 1636.

• CAS Number:

  1009817-63-3