Epothilone B

• Background :

  Epothilone are a new class of cancer drugs. They prevent cancer cells from dividing by interfering with tubulin (1). Epithilone B possess the same biological effects as paclitaxel in both invitro and cultured cells, because they share the same binding site (2). Epothilone has also been shown to induce tubulin polymerization into microtubules without the presence of GTP. And it also causes cell cycle arrest at the G2-M transition phase, leading to eventual cell apoptosis (3). It is considered Neurotrophic - it has been found to promote axon regeneration.

• Description :

  Microtubule stabilizer

• Product Name Alternative :

  (1S,3S,7S,10R,11S,12S,16R) -7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-[ (1E) -1- (2-methyl-1,3-thiazol-4-yl) -1-propen-2-yl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione, Patupilone

• UNSPSC :

  41116105

• Type :

  Inducer

• Source :

  Synthetic

• Field of Research :

  Cancer | Apoptosis | Neuroscience | Cell Markers | Neuron Markers | Axon Markers

• Purity :

  >98%

• Weight :

  0.001

• Format :

  White Solid

• Solubility :

  Soluble to 10 mM in DMSO

• Molecular Formula :

  C27H41NO6S

• Molecular Weight :

  507.68

• Precautions :

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations :

  1. Rosenberg S., Devita V.T., Hellman S. (2005) Cancer: Principles & Practice of Oncology: Lippincott Williams and Wilkins. 2. Julien B., Shah S. (2002) Antimicrob Agents Chemother. 46(9): 2772. 3. Balog D.M., et al. (1996) Angew Chem. 108: 2976. 4. J Ruchel et al. Science 2015, 348: 347-352

• CAS Number :

  152044-54-7