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Epothilone B

CAT: 0400-SIH-238-1MGSize: 1 mgDry Ice: NoHazardous: No
CAT#:0400-SIH-238-1MGSize:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Epothilone are a new class of cancer drugs. They prevent cancer cells from dividing by interfering with tubulin (1). Epithilone B possess the same biological effects as paclitaxel in both invitro and cultured cells, because they share the same binding site (2). Epothilone has also been shown to induce tubulin polymerization into microtubules without the presence of GTP. And it also causes cell cycle arrest at the G2-M transition phase, leading to eventual cell apoptosis (3). It is considered Neurotrophic - it has been found to promote axon regeneration.
Description
Microtubule stabilizer
CAS Number
152044-54-7
Product Name Alternative
(1S,3S,7S,10R,11S,12S,16R) -7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-[ (1E) -1- (2-methyl-1,3-thiazol-4-yl) -1-propen-2-yl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione, Patupilone
UNSPSC
41116105
Type
Inducer
Source
Synthetic
Field of Research
Cancer | Apoptosis | Neuroscience | Cell Markers | Neuron Markers | Axon Markers
Purity
>98%
Weight
0.001
Format
White Solid
Solubility
Soluble to 10 mM in DMSO
Molecular Formula
C27H41NO6S
Molecular Weight
507.68
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Rosenberg S., Devita V.T., Hellman S. (2005) Cancer: Principles & Practice of Oncology: Lippincott Williams and Wilkins. 2. Julien B., Shah S. (2002) Antimicrob Agents Chemother. 46(9): 2772. 3. Balog D.M., et al. (1996) Angew Chem. 108: 2976. 4. J Ruchel et al. Science 2015, 348: 347-352

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