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Celastrol

CAT: 0400-SIH-333-10MGSize: 10 mgDry Ice: NoHazardous: No
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CAT#:0400-SIH-333-10MGSize:10 mg
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Background
Displays potent antioxidant and anti-inflammatory activity. Inhibits NFB (IC50=270 nM). It induces heat shock response and cytoprotection in various cells. It inhibits 20S proteasome chymotrypsin activity (IC50=2.5 M). Cell permeable.
Description
Proteasome inhibitor
CAS Number
34157-83-0
Product Name Alternative
3-​hydroxy-​9β, ​13α-​dimethyl-​2-​oxo-​24, ​25, ​26-​trinoroleana-​1 (10), ​3, ​5, ​7-​tetraen-​29-​oic acid, 10-Hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydro-picene-2-carboxylic acid, Tripterin
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cancer | Apoptosis | Cancer Growth Inhibitors | Proteasome Inhibitors
Purity
>98%
Weight
0.01
Format
Red Powder
Solubility
Soluble in 45 mg/ml DMSO, 30 mg/ml Ethanol
Molecular Formula
C29H38O4
Molecular Weight
450.6
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Sethi G., et al. (2007) Blood109: 2727. 2. Westerheide S.D., et al. (2004) J. Biol. Chem. 279: 56053. 3. Yang H., et al. (2006) Cancer Res. 66: 4758.

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CatalogName
200694Celastrol

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