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Celastrol (Standard)

CAT: 0804-HY-13067R-05Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-13067R-05Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Celastrol (Standard) is the analytical standard of Celastrol. This product is intended for research and analytical applications. Celastrol (Tripterine; Tripterin) is a proteasome inhibitor which potently and preferentially inhibits the chymotrypsin-like activity of a purified 20S proteasome with IC50 of 2.5 μM.
CAS Number
34157-83-0
Product Name Alternative
Tripterine (Standard) ; Tripterin (Standard)
UNSPSC
12352211
Hazard Statement
H301
Target
Apoptosis; Autophagy; Endogenous Metabolite; Mitophagy; Proteasome; Reference Standards
Type
Reference Standards
Related Pathways
Apoptosis; Autophagy; Metabolic Enzyme/Protease; Others
Field of Research
Inflammation/Immunology; Cancer
Assay Protocol
https://www.medchemexpress.com/celastrol-standard.html
Purity
99.91
Smiles
OC1=C(C2=CC=C3[C@](C)([C@]4(CC[C@]3(C2=CC1=O)C)C)CC[C@@]5(C)CC[C@@](C(O)=O)(C[C@]54[H])C)C
Molecular Formula
C29H38O4
Molecular Weight
450.61
Precautions
H301
References & Citations
[1]Yang H, et al. Celastrol, a triterpene extracted from the Chinese "Thunder of God Vine, " is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice. Cancer Res. 2006 May 1;66 (9) :4758-65|[2]Guan Y, et al. Celastrol attenuates oxidative stress in the skeletal muscle of diabetic rats by regulating the AMPK-PGC1α-SIRT3 signaling pathway. Int J Mol Med. 2016 May;37 (5) :1229-38.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, sealed storage, away from light and moisture
Scientific Category
Reference Standards

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