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MlN4924

CAT: 0400-SIH-331-200UGSize: 200 µgDry Ice: NoHazardous: No
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CAT#:0400-SIH-331-200UGSize:200 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Potent and selective NEDD8-activating enzyme (NAE) inhibitor. It disrupts cullin-RING ligase-mediated protein turnover leading to apoptosis in human tumor cells. It suppresses the growth of human tumor xenografts in mice. Cell permeable.
Description
NEDD8 activating enzyme inhibitor
CAS Number
905579-51-3
Product Name Alternative
[ (1S,2S,4R) -4-{4-[ (1S) -2,3-Dihydro-1H-inden-1-ylamino]-7H-pyrrolo[2,3-d]pyrimidin-7-yl}-2-hydroxycyclopentyl]methyl sulfamate, Sulfamic acid
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cancer | Apoptosis
Purity
>98%
Weight
0.0002
Format
White Powder
Solubility
Soluble in 10 mg/ml DMSO
Molecular Formula
C21H25N5O4S
Molecular Weight
443.2
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Soucy T.A., et al. (2009) Nature. 458:732. 2. Milhollen M.A., et al. (2010) Blood. 116:1515.

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