MlN4924

• Background:

  Potent and selective NEDD8-activating enzyme (NAE) inhibitor. It disrupts cullin-RING ligase-mediated protein turnover leading to apoptosis in human tumor cells. It suppresses the growth of human tumor xenografts in mice. Cell permeable.

• Description:

  NEDD8 activating enzyme inhibitor

• Product Name Alternative:

  [ (1S,2S,4R) -4-{4-[ (1S) -2,3-Dihydro-1H-inden-1-ylamino]-7H-pyrrolo[2,3-d]pyrimidin-7-yl}-2-hydroxycyclopentyl]methyl sulfamate, Sulfamic acid

• UNSPSC:

  41116105

• Type:

  Inhibitor

• Source:

  Synthetic

• Field of Research:

  Cancer | Apoptosis

• Purity:

  >98%

• Weight:

  0.001

• Format:

  White Powder

• Solubility:

  Soluble in 10 mg/ml DMSO

• Molecular Formula:

  C21H25N5O4S

• Molecular Weight:

  443.2

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Soucy T.A., et al. (2009) Nature. 458:732. 2. Milhollen M.A., et al. (2010) Blood. 116:1515.

• CAS Number:

  905579-51-3