Pyr-41

• Background:

  Inhibits ubiquitin activating enzyme E1 (>60% inhibition at 10 µM) with little or no activity against E2 or E3. Cell permeable.

• Description:

  Ubiquitin-Activating Enzyme (E1) Inhibitor

• Product Name Alternative:

  Ethyl 4-{ (4Z) -4-[ (5-nitro-2-furyl) methylene]-3,5-dioxo-1-pyrazolidinyl}benzoate, PYR-41, 4[4- (5-Nitro-furan-2-ylmethylene) -3,5-dioxo-pyrazolidin-1-yl]-benzoic acid ethyl ester

• UNSPSC:

  41116105

• Type:

  Inhibitor

• Source:

  Synthetic

• Field of Research:

  Cancer | Apoptosis

• Purity:

  >98%

• Weight:

  0.005

• Format:

  Brown Powder

• Solubility:

  Soluble in 25 mg/ml DMSO

• Molecular Formula:

  C17H13N3O7

• Molecular Weight:

  371.3

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Yang Y., et al. (2007) Cancer Res. 67: 9472. 2. Mi L., et al. (2009) J. Biol. Chem. 284: 17039.

• CAS Number:

  418805-02-4