Pyr3

• Background:

  Pyr3, a novel pyrazole, selectively inhibits TRPC3 channels. In B lymphocytes, Pyr3 eliminated the B cell receptor-induced Ca2+ oscillation regulated by TRPC3-mediated Ca2+ influx. In the cardiac system, Pyr3 attenuates activation of nuclear factor of activated T cells and hypertrophic growth in myocytes and pressure overloaded-induced hypertrophy in vivo (1).

• Description:

  TRPC3 Channel blocker

• Product Name Alternative:

  Ethyl 1-{4-[ (2,3,3-trichloroacryloyl) amino]phenyl}-5- (trifluoromethyl) -1H-pyrazole-4-carboxylate

• UNSPSC:

  41116105

• Type:

  Inhibitor

• Source:

  Synthetic

• Field of Research:

  Neuroscience | Ion Channels | Transient Receptor Potential (TRP) Channels

• Purity:

  >98%

• Weight:

  0.05

• Format:

  White Solid

• Solubility:

  Soluble to 100 mM in DMSO

• Molecular Formula:

  C16H11Cl3F3N3O3

• Molecular Weight:

  456.63

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Kiyonaka S., Kato K., Nishida M., and Mori Y. (2010) Yakugaku Zasshi. 130(3): 303-311.

• CAS Number:

  1160514-60-2