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Pyr3

CAT: 0400-SIH-306-50MGSize: 50 mgDry Ice: NoHazardous: No
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CAT#:0400-SIH-306-50MGSize:50 mg
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Background
Pyr3, a novel pyrazole, selectively inhibits TRPC3 channels. In B lymphocytes, Pyr3 eliminated the B cell receptor-induced Ca2+ oscillation regulated by TRPC3-mediated Ca2+ influx. In the cardiac system, Pyr3 attenuates activation of nuclear factor of activated T cells and hypertrophic growth in myocytes and pressure overloaded-induced hypertrophy in vivo (1).
Description
TRPC3 Channel blocker
CAS Number
1160514-60-2
Product Name Alternative
Ethyl 1-{4-[ (2,3,3-trichloroacryloyl) amino]phenyl}-5- (trifluoromethyl) -1H-pyrazole-4-carboxylate
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Neuroscience | Ion Channels | Transient Receptor Potential (TRP) Channels
Purity
>98%
Weight
0.05
Format
White Solid
Solubility
Soluble to 100 mM in DMSO
Molecular Formula
C16H11Cl3F3N3O3
Molecular Weight
456.63
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Kiyonaka S., Kato K., Nishida M., and Mori Y. (2010) Yakugaku Zasshi. 130(3): 303-311.

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