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Sulindac Sulfide

CAT: 0400-SIH-261-50MGSize: 50 mgDry Ice: NoHazardous: No
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CAT#:0400-SIH-261-50MGSize:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Sulindac is a nonsteroidal anti-inflammatory drug that is known to prevent recurrence and reduce colorectal polyps. It is a prodrug that is metabolized to a sulfide and sulfone derivative in vivo. The mechanism of action of both is the selective induction of apoptosis. The anti-inflammatory properties of sulindac are mediated by COX inhibition (1, 2).
Description
COX inhibitor
CAS Number
32004-67-4
Product Name Alternative
{ (1Z) -5-Fluoro-2-methyl-1-[4- (methylsulfanyl) benzylidene]-1H-inden-3-yl}acetic acid
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cancer | Apoptosis
Purity
>98%
Weight
0.05
Format
Yellow solid
Solubility
Soluble to 25 mM in DMSO, 3 mM in ethanol
Molecular Formula
C20H17FO2S
Molecular Weight
340.41
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Frahm S., et al. (2004) Cancer Cell Int. 4:4. 2. Piazza G.A., et al. (1997) Cancer Res. 57(12): 2452-2459.

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