Sulindac Sulfide
CAT:
400-SIH-261-50MG
Size:
50 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Sulindac Sulfide
- Background: Sulindac is a nonsteroidal anti-inflammatory drug that is known to prevent recurrence and reduce colorectal polyps. It is a prodrug that is metabolized to a sulfide and sulfone derivative in vivo. The mechanism of action of both is the selective induction of apoptosis. The anti-inflammatory properties of sulindac are mediated by COX inhibition (1, 2).
- Description: COX inhibitor
- Alternative Name: {(1Z)-5-Fluoro-2-methyl-1-[4-(methylsulfanyl)benzylidene]-1H-inden-3-yl}acetic acid
- CAS Number: 32004-67-4
- UNSPSC: 41116105
- Source: Synthetic
- Purity: >98%
- Weight: 0.05
- Format: Yellow solid
- Solubility: Soluble to 25 mM in DMSO, 3 mM in ethanol
- Molecular Formula: C20H17FO2S
- Molecular Weight: 340.41
- Precautions: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
- References & Citations: 1. Frahm S., et al. (2004) Cancer Cell Int. 4:4. 2. Piazza G.A., et al. (1997) Cancer Res. 57(12): 2452-2459.