Vinblastine sulfate

• Background:

  Vinblastine sulfate is used clinically as a cancer chemotherapeutic agent. It disrupts normal microtubule assembly. Vinblastine also inhibits autophagy by obstructing autophagosome maturation and by stopping the fusion event of autophagosomes with lysosomes.

• Description:

  Cell cycle blocker

• Product Name Alternative:

  Vincaleukoblastine

• UNSPSC:

  41116105

• Type:

  Inhibitor

• Source:

  Synthetic

• Field of Research:

  Cancer | Autophagy

• Purity:

  ≥98%

• Weight:

  0.025

• Format:

  White powder.

• Solubility:

  Soluble in DMSO, methanol or water (25 mg/ml).

• Molecular Formula:

  C46H58N4O9•H2SO4

• Molecular Weight:

  909.1

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Veldhoen R.A., et al. (2013) Oncogene. 32(6): 736-46. 2. Adiseshaiah P.P., et al. (2013) Cancer Lett. 337(2): 254-65.

• CAS Number:

  143-67-9