Sulindac Sulfide

• Background:

  Sulindac is a nonsteroidal anti-inflammatory drug that is known to prevent recurrence and reduce colorectal polyps. It is a prodrug that is metabolized to a sulfide and sulfone derivative in vivo. The mechanism of action of both is the selective induction of apoptosis. The anti-inflammatory properties of sulindac are mediated by COX inhibition (1, 2).

• Description:

  COX inhibitor

• Product Name Alternative:

  { (1Z) -5-Fluoro-2-methyl-1-[4- (methylsulfanyl) benzylidene]-1H-inden-3-yl}acetic acid

• UNSPSC:

  41116105

• Type:

  Inhibitor

• Source:

  Synthetic

• Field of Research:

  Cancer | Apoptosis

• Purity:

  >98%

• Weight:

  0.01

• Format:

  Yellow solid

• Solubility:

  Soluble to 25 mM in DMSO, 3 mM in ethanol

• Molecular Formula:

  C20H17FO2S

• Molecular Weight:

  340.41

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Frahm S., et al. (2004) Cancer Cell Int. 4:4. 2. Piazza G.A., et al. (1997) Cancer Res. 57(12): 2452-2459.

• CAS Number:

  32004-67-4