Irinotecan HCl

• Background :

  Irinotecan is a topoisomerase 1 inhibitor, which prevents DNA from unwinding. Chemically it is a semisynthetic analogue of the natural alkaloid camptothecin. It is activated by hydrolysis to SN-38 which is then inactivated by glucuronidation by UGT1A1. This inactivation eventually leads to inhibition of both DNA replication and transcription (1, 2).

• Description :

  Topoisomerase I inhibitor

• Product Name Alternative :

  (4S) -4,11-Diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl 1,4'-bipiperidine-1'-carboxylate, CPT11, Camptothecin 11

• UNSPSC :

  41116105

• Type :

  Inducer

• Source :

  Synthetic

• Field of Research :

  Cancer | Apoptosis

• Purity :

  >98%

• Weight :

  0.05

• Format :

  Yellow solid

• Solubility :

  Soluble to 50 mg/ml in DMSO

• Molecular Formula :

  C33H38N4O6•HCl

• Molecular Weight :

  623.14

• Precautions :

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations :

  1. Innocentri F., et al. (2004) J Clin. Oncol. 22(8): 1382-1388. 2. O'Dwyer P.J., and Catalano R.B. (2006) J Clin Oncol. 24(28): 4534-4538.

• CAS Number :

  100286-90-6