Irinotecan HCl

CAT: 0400-SIH-243-250MGSize: 250 mgDry Ice: NoHazardous: No
CAT#:0400-SIH-243-250MGSize:250 mg
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Background
Irinotecan is a topoisomerase 1 inhibitor, which prevents DNA from unwinding. Chemically it is a semisynthetic analogue of the natural alkaloid camptothecin. It is activated by hydrolysis to SN-38 which is then inactivated by glucuronidation by UGT1A1. This inactivation eventually leads to inhibition of both DNA replication and transcription (1, 2).
Description
Topoisomerase I inhibitor
CAS Number
100286-90-6
Product Name Alternative
(4S) -4,11-Diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl 1,4'-bipiperidine-1'-carboxylate, CPT11, Camptothecin 11
UNSPSC
41116105
Type
Inducer
Source
Synthetic
Field of Research
Cancer | Apoptosis
Purity
>98%
Weight
0.25
Format
Yellow solid
Solubility
Soluble to 50 mg/ml in DMSO
Molecular Formula
C33H38N4O6•HCl
Molecular Weight
623.14
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Innocentri F., et al. (2004) J Clin. Oncol. 22(8): 1382-1388. 2. O'Dwyer P.J., and Catalano R.B. (2006) J Clin Oncol. 24(28): 4534-4538.

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