Taxol

• Background:

  Paclitaxel is a mitotic inhibitor that promotes and stabilizes tubulin polymerization, causing cell cycle arrest (1). Induces autocatalytic activation of caspase-10 in CCRF-HSB-2 cells, triggering apoptosis (2).

• Description:

  Microtubule stabilizer

• Product Name Alternative:

  (2α,5β,7β,10β,13α) -4,10-Diacetoxy-13-{[ (2R,3S) -3- (benzoylamino) -2-hydroxy-3-phenylpropanoyl]oxy}-1,7-dihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate, Paclitaxel

• UNSPSC:

  41116105

• Type:

  Inducer

• Source:

  Synthetic

• Field of Research:

  Cancer | Apoptosis

• Purity:

  >98% (TLC) ; NMR (Conforms)

• Weight:

  0.01

• Format:

  White solid

• Solubility:

  Soluble in DMSO, ethanol or acetonitrile

• Molecular Formula:

  C47H51NO14

• Molecular Weight:

  853.9

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Wani M., Taylor H., Wall M., Coggon P., and McPhail A. (1971) J Am Chem Soc. 93(9): 2325-2327. 2. Park S.J., et al. (2004) J Biol Chem. 279(49): 51057-51067.

• CAS Number:

  33069-62-4