Cyclopamine

• Background:

  Cyclopamine is a hedgehog signaling pathway inhibitor that influences the balance between the active and inactive forms of the Smoothened protein (1). It is being investigated as a treatment agent in basal cell carcinoma, medulloblastoma and rhabdomyosarcoma (1, 2). Cyclopamine is also being investigated as a novel regulator of γ-secretase-mediated cleavage of APP (3).

• Description:

  Hedgehog signaling blocker

• Product Name Alternative:

  (3β,22S,23R) -17,23-Epoxyveratraman-3-ol

• UNSPSC:

  41116105

• Type:

  Inhibitor

• Source:

  Synthetic

• Field of Research:

  Cancer | Apoptosis | Cancer Growth Inhibitors | Hedgehog Pathway Inhibitors | Neuroscience | Neurodegeneration | Alzheimer's Disease | Tangles & Tau |Amyloid

• Purity:

  >98%

• Weight:

  0.001

• Format:

  White Solid

• Solubility:

  Soluble to 5 mM in ethanol

• Molecular Formula:

  C27H41NO2

• Molecular Weight:

  434.15

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Beachy P.A., et al. (2000) Nature. 406(6799): 1005-1009. 2. Yauch R.L., et al. (2009) Science. 326(5952): 572-574. 3. Vorobyeva A.G., et al. (2014) J Biol Chem. 289(48): 33258-33274.

• CAS Number:

  4449-51-8