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Amifostine

CAT: 0400-SIH-210-50MGSize: 50 mgDry Ice: NoHazardous: No
CAT#:0400-SIH-210-50MGSize:50 mg
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Background
Amifostine is a cytoprotective adjuvant used in cancer chemotherapy and radiotherapy. Inside cells it detoxifies reactive metabolites of platinum and alkylating agents (1, 2). Other effects include accelerated DNA repair (1), induction of cellular hypoxia (1), inhibition of apoptosis (2), alteration of gene expression (2) and modification of enzyme activity (2).
Description
HIF-1α activator
CAS Number
20537-88-6
Product Name Alternative
S-{2-[ (3-Aminopropyl) amino]ethyl} dihydrogen phosphorothioate
UNSPSC
41116105
Type
Activator
Source
Synthetic
Field of Research
Cancer | Apoptosis
Purity
>98%
Weight
0.05
Format
White Solid
Solubility
Soluble in water
Molecular Formula
C5H15N2O3PS
Molecular Weight
214.22
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Kouvaris J.R., Kouloulias V.E., Blahos L.J. (2007) Oncologist. 12(6): 738-747. 2. Amifostine: BC Cancer Agency. 2006-03-01.

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