Amifostine

• Background:

  Amifostine is a cytoprotective adjuvant used in cancer chemotherapy and radiotherapy. Inside cells it detoxifies reactive metabolites of platinum and alkylating agents (1, 2). Other effects include accelerated DNA repair (1), induction of cellular hypoxia (1), inhibition of apoptosis (2), alteration of gene expression (2) and modification of enzyme activity (2).

• Description:

  HIF-1α activator

• Product Name Alternative:

  S-{2-[ (3-Aminopropyl) amino]ethyl} dihydrogen phosphorothioate

• UNSPSC:

  41116105

• Type:

  Activator

• Source:

  Synthetic

• Field of Research:

  Cancer | Apoptosis

• Purity:

  >98%

• Weight:

  0.01

• Format:

  White Solid

• Solubility:

  Soluble in water

• Molecular Formula:

  C5H15N2O3PS

• Molecular Weight:

  214.22

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Kouvaris J.R., Kouloulias V.E., Blahos L.J. (2007) Oncologist. 12(6): 738-747. 2. Amifostine: BC Cancer Agency. 2006-03-01.

• CAS Number:

  20537-88-6