Ebselen

• Background:

  Ebselen or 2-phenyl-1, 2-benzisoselenazol-3(2H)-one (also called PZ 51 or DR3305), is a mimic of glutathione peroxidase and can also react with peroxynitrite (1). It is being investigated as a possible treatment for reperfusion injury and stroke (2, 3), as well as tinnitus (4). Ebselen is a potent scavenger of hydrogen peroxide as well as hydroperoxides including membrane bound phospholipid and cholesterylester hydroperoxides.

• Description:

  Glutathione peroxidase mimic

• Product Name Alternative:

  2-Phenyl-1,2-benzoselenazol-3 (2H) -one

• UNSPSC:

  41116105

• Type:

  Inhibitor

• Source:

  Synthetic

• Field of Research:

  Cancer | Apoptosis

• Purity:

  >99%

• Weight:

  0.05

• Format:

  Off-white Solid

• Solubility:

  Soluble in DMSO and 100% ethanol

• Molecular Formula:

  C13H9NOSe

• Molecular Weight:

  274.18

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Schewe T. (1995) Gen Pharmacol. 26(6): 1153-1169. 2. Parnham M., Seis H. (2000) Expert Opin Investig Drugs. 9(3): 607-619. 3. Yamaguchi T., et al. (1998) Stroke. 29(1): 12-17. 4. Kil J., Pierce C., Tran H., Gu R., Lynch E.D. (2007) Hearing Research. 226(1-2): 44-51.

• CAS Number:

  60940-34-3