115-7C

• Background:

  115-7c activates Hsp70 ATPase turnover rate and promotes Hsp70 substrate refolding. It binds to the IIA subdomain of DnaK and promotes the DnaK-DnaJ complex. Equivalent with SW02.

• Description:

  Hsp70 Activator

• Product Name Alternative:

  4- (5- ((benzyloxy) carbonyl) -4- (2,4-dichlorophenyl) -6-methyl-2-oxo-3,4-dihydropyrimidin-1 (2H) -yl) butanoic acid, SWO2

• UNSPSC:

  41116105

• Type:

  Activator

• Source:

  Synthetic

• Field of Research:

  Cancer | Heat Shock

• Purity:

  >98%

• Weight:

  0.025

• Format:

  White Solid

• Solubility:

  Soluble in DMSO (20 mg/ml)

• Molecular Formula:

  C23H22Cl2N2O5

• Molecular Weight:

  477.34

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Wisen et al., (2010) ACS Chem. Biol., 5: 611-622. 2. Jinwal et al. (2009) J.Neurosci. 29:12079. 3. Chafekar et al. (2012) ACS Chem Biol. 7:1556. 4. Walter et al. (2011) J. Biol. Chem. 286:40486