Compound 115-7c

• Background:

  Acts as an artificial co-chaperone for HSP701. The activity of compound 115-7c mirrors those of HSP40 stimulating the ATPase and protein-folding activities of prokaryotic HSP70. Increases tau levels in cell lines overexpressing tau2. Induces solubilization of polyglutamine and exacerbates polyQ-mediated toxicity3,4. An important probe for understanding HSP70 functions4

• Conjugation:

  Unconjugated

• Buffer:

  Off-white solid

• Storage Conditions:

  -20°C