Hsp70 TKD Peptide

CAT: 0400-SIH-118ASize: 1 mgDry Ice: NoHazardous: No
CAT#:0400-SIH-118ASize:1 mg
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Background
Hsp70 genes encode abundant heat-inducible 70-kDa hsps (hsp70s). In most eukaryotes hsp70 genes exist as part of a multigene family. They are found in most cellular compartments of eukaryotes including nuclei, mitochondria, chloroplasts, the endoplasmic reticulum and the cytosol, as well as in bacteria. The genes show a high degree of conservation, having at least 5O% identity (1). The N-terminal two thirds of hsp70s are more conserved than the C-terminal third. Hsp70 binds ATP with high affinity and possesses a weak ATPase activity which can be stimulated by binding to unfolded proteins and synthetic peptides (2). When hsc70 (constitutively expressed) present in mammalian cells was truncated, ATP binding activity was found to reside in an N-terminal fragment of 44 kDa which lacked peptide binding capacity. Polypeptide binding ability therefore resided within the Cterminal half (3). The structure of this ATP binding domain displays multiple features of nucleotide binding proteins (4). Heat shock protein 70 has also been found to have a high degree of plasma membrane localization in tumour cell lines. This is correlated with increased sensitivity to lysis mediated by natural killer (NK) cells. The TKD peptide is a partial hsp70 sequence (TKDNNLLGRFELSG- aa. 450-463) and has identical effects on NK cells as full-length Hsp70 protein, being able to stimulate natural killer cells activity at equivalent concentrations to full-length Hsp70 protein (5). Incubation of peripheral blood lymphocyte cells with TKD plus low-dose interleukin 2 (IL-2) enhances the cytolytic activity of NK cells against Hsp70 membrane-positive tumors, in vitro and in vivo (6). Looking for more information on HSP70? Visit our new HSP70 Scientific Resource Guide at http://www.HSP70.com.
Description
Hsp70 Peptide
UNSPSC
41116105
Type
Activator
Source
Synthetic
Field of Research
Cancer | Heat Shock
Purity
>98%
Weight
0.001
Format
Solid
Solubility
In aqueous solution
Molecular Formula
TKDNNLLGRFELSG
Molecular Weight
1363
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Boorstein W. R., Ziegelhoffer T. & Craig E. A. (1993) J.Mol. Evol.38(1): 1-17. 2. Rothman J. (1989), Cell 59: 591 -601. 3. DeLuca-Flaherty et al. (1990) Cell 62: 875-887. 4. Bork P., Sander C. & Valencia A. (1992) Proc. Natl Acad. Sci. USA 89:7290-7294. 5. Multhoff G., et al. (2001) Cell Stress Chaperones 6 (4): 337-344. 6. Krause, S. W. et al. (2004) Clin. Cancer Res. 10(11): 3699-3707.

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