HSP70 Protein

CAT: 0400-SPR-117BSize: 100 µgDry Ice: NoHazardous: No
CAT#:0400-SPR-117BSize:100 µg
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
HSP70 is a highly inducible molecular chaperone that plays a pivotal role in protein quality control across all major cellular compartments. In the brain, HSP70 is essential for preventing the aggregation of misfolded proteins, a key pathological feature of neurodegenerative diseases. HSP70 binds to nascent and partially folded polypeptides, stabilizing them and facilitating proper folding or directing them toward degradation pathways. This function is particularly critical in conditions such as Alzheimer’s, Parkinson’s, and ALS, where protein aggregation and impaired proteostasis drive neuronal dysfunction and cell death. The chaperone activity of HSP70 is regulated by ATP binding and hydrolysis, which triggers conformational changes that control substrate binding and release. Its ability to recognize hydrophobic regions of unfolded proteins enables it to suppress aggregation and promote cellular recovery from stress. Therapeutic strategies aimed at enhancing HSP70 expression or activity are under investigation for their potential to reduce neurotoxicity, improve protein clearance, and slow disease progression in neurodegenerative disorders.
Description
Human Recombinant HSP70 Full Length Protein
Product Name Alternative
HSPA1A, HSPA1B, HSPA1, HSP70, HSP70-1, HSP70.1, HSP70-2, HSP72, HSP73, HSX70, Heat shock 70 kDa protein 1A, Heat shock 70 kDa protein 1B
UNSPSC
12352202
UN Code
Non-hazardous
Hazard Statement
Non-hazardous
Gene ID
3303
Swiss Prot
P0DMV8/P0DMV9
Accession Number
M11717
Cellular Locus
Cytoplasm
Expression System
Baculovirus/Sf9
Host
Baculovirus/Sf9 cells
Origin Species
Human
Target
HSP70
Conjugation
No tag
Nature
Recombinant
Sequence
MAKAAAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDPVVQSDMKHWPFQVINDGDKPKVQVSYKGETKAFYPEEISSMVLTKMKEIAEAYLGYPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVNHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTGASLEIDSLFEGIDFYTSITRARFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVGYGAAVQAAILMGDKSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRFELSCIPPAPGVPQIEVTFDIDANGILNVTATKDSTGKANKITITNDKGRLSKEEIERMVQEAEKYKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWLDANTLAEKDEFEHKRKELEQVCNPIISGLYQGAGGPGPGGFGAQGPKGGSGSGPTIEEVD
Applications
WB | SDS-PAGE | ATPase Activity Assay | Functional Assay | ELISA
Field of Research
Cancer | Heat Shock | Cell Signaling | Protein Trafficking | Chaperone Proteins | Cancer | Tumor Biomarkers
Purification Method
Multi-Step Purified | Endotoxin-free
Purification
Multi-Step Purified | Endotoxin-free
Limit Of Detection
This product has been certified >90% pure using SDS-PAGE analysis. The protein tested positive for ATPase activity using a Malachite Green assay.
Concentration
Lot/batch specific. See included datasheet.
Purity
>90%
Weight
0.1
Length
Full Length
Buffer
50mM Tris/HCl pH7.5, 0.3M NaCl, 10% glycerol, 0.1mM EDTA
Molecular Weight
~70 kDa
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For research use only.
References & Citations
1. Zho J. (1998) Cell. 94: 471-480. 2. Boorstein W. R., Ziegelhoffer T. & Craig E. A. (1993) J. Mol. Evol.38(1): 1-17. 3. Rothman J. (1989) Cell. 59: 591 -601. 4. DeLuca-Flaherty et al. (1990) Cell. 62: 875-887. 5. Bork P., Sander C. & Valencia A. (1992) Proc. Natl Acad. Sci. USA. 89: 7290-7294. 6. Fink A.L. (1999) Physiol. Rev. 79: 425-449.
Shipping Conditions
Blue Ice or 4ºC
Storage Conditions
-20ºC
Protein Length
Full Length
Background Reference 01
1. Zho J. (1998) Cell. 94: 471-480. 2. Boorstein W. R., Ziegelhoffer T. & Craig E. A. (1993) J. Mol. Evol.38 (1) : 1-17. 3. Rothman J. (1989) Cell. 59: 591 -601. 4. DeLuca-Flaherty et al. (1990) Cell. 62: 875-887. 5. Bork P., Sander C. & Valencia A. (1992) Proc. Natl Acad. Sci. USA. 89: 7290-7294. 6. Fink A.L. (1999) Physiol. Rev. 79: 425-449.
Location
Cytoplasm
AA Sequence
MAKAAAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDPVVQSDMKHWPFQVINDGDKPKVQVSYKGETKAFYPEEISSMVLTKMKEIAEAYLGYPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVNHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTGASLEIDSLFEGIDFYTSITRARFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVGYGAAVQAAILMGDKSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRFELSCIPPAPGVPQIEVTFDIDANGILNVTATKDSTGKANKITITNDKGRLSKEEIERMVQEAEKYKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWLDANTLAEKDEFEHKRKELEQVCNPIISGLYQGAGGPGPGGFGAQGPKGGSGSGPTIEEVD
Immunogen Species
Human
Product MSDS
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