GRP78 (Bip) Protein

GRP78, also known as BiP (Binding Immunoglobulin Protein), is a key endoplasmic reticulum (ER) chaperone involved in protein folding, quality control, and the unfolded protein response (UPR) . It is a member of the HSP70 family and is upregulated during ER stress to maintain cellular homeostasis. In neuroscience, GRP78 plays a protective role against ER stress-induced apoptosis, a common feature in neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and ALS. Neurons are particularly sensitive to disruptions in protein folding, and GRP78 helps mitigate this by stabilizing misfolded proteins and regulating UPR signaling pathways. Reduced GRP78 expression has been observed in the brains of Alzheimer’s patients, correlating with increased protein aggregation and neuronal loss. Conversely, upregulation of GRP78 has been shown to confer neuroprotection in models of glutamate toxicity and oxidative stress. GRP78 also influences neurodevelopment and synaptic plasticity, making it a critical factor in both disease and normal brain function. Its role in modulating ER stress responses positions it as a potential biomarker and therapeutic target for neurodegenerative and neuroinflammatory disorders.

Human Recombinant GRP78 (Bip) Full Length Protein

BiP, GRP78, HSPA5, MIF2, Immunoglobulin heavy chain binding

12352202

Non-hazardous

Non-hazardous

3309

P11021

NM_005347

Endoplasmic Reticulum Lumen | Melanosome

E. coli

GRP78 (Bip)

No tag

Recombinant

MKLSLVAAMLLLLSAARAEEEDKKEDVGTVVGIDLGTTYSCVGVFKNGRVEIIANDQGNRITPSYVAFTPEGERLIGDAAKNQLTSNPENTVFDAKRLIGRTWNDPSVQQDIKFLPFKVVEKKTKPYIQVDIGGGQTKTFAPEEISAMVLTKMKETAEAYLGKKVTHAVVTVPAYFNDAQRQATKDAGTIAGLNVMRIINEPTAAAIAYGLDKREGEKNILVFDLGGGTFDVSLLTIDNGVFEVVATNGDTHLGGEDFDQRVMEHFIKLYKKKTGKDVRKDNRAVQKLRREVEKAKRALSSQHQARIEIESFYEGEDFSETLTRAKFEELNMDLFRSTMKPVQKVLEDSDLKKSDIDEIVLVGGSTRIPKIQQLVKEFFNGKEPSRGINPDEAVAYGAAVQAGVLSGDQDTGDLVLLDVCPLTLGIETVGGVMTKLIPRNTVVPTKKSQIFSTASDNQPTVTIKVYEGERPLTKDNHLLGTFDLTGIPPAPRGVPQIEVTFEIDVNGILRVTAEDKGTGNKNKITITNDQNRLTPEEIERMVNDAEKFAEEDKKLKERIDTRNELESYAYSLKNQIGDKEKLGGKLSSEDKETMEKAVEEKIEWLESHQDADIEDFKAKKKELEEIVQPIISKLYGSAGPPPTGEEDTAEKDEL

WB | SDS-PAGE | ATPase Activity Assay | Functional Assay | ELISA

Cancer | Heat Shock | Cell Signaling | Protein Trafficking | Chaperone Proteins | Organelle Markers

Affinity Purified

Affinity Purified

This product has been certified >90% pure using SDS-PAGE analysis and gamma globulin as the protein concentration standard.

Lot/batch specific. See included datasheet.

>90%

0.05

Full Length

20mM Tris/HCl pH7.5, 50mM KCl, 5mM MgCl2, 1mM DTT

~78 kDa

Not for use in humans. Not for use in diagnostics or therapeutics. For research use only.

1. Cho S., et al (2007) Mol Cell Biol. 27(1): 368-83. 2. Yang Y., et al. (1998) J Biol Chem. 273: 25552-25555. 3. Luo S., et al (2006) 26(15): 5688-97. 4. Yu Z., et al. (1999) Exp Neurol. 15: 302-314. 5. Koomagi R., et al. (1999) Anticancer Res. 19: 4333-4336. 6. Laquerre S., et al. (1998) J. Virology. 72: 4940-4949. 7. Dong D., et al. (2005) Cancer Res. 65(13): 5785-91.

Blue Ice or 4ºC

-20ºC

Full Length

1. Cho S., et al (2007) Mol Cell Biol. 27 (1) : 368-83. 2. Yang Y., et al. (1998) J Biol Chem. 273: 25552-25555. 3. Luo S., et al (2006) 26 (15) : 5688-97. 4. Yu Z., et al. (1999) Exp Neurol. 15: 302-314. 5. Koomagi R., et al. (1999) Anticancer Res. 19: 4333-4336. 6. Laquerre S., et al. (1998) J. Virology. 72: 4940-4949. 7. Dong D., et al. (2005) Cancer Res. 65 (13) : 5785-91.

Endoplasmic Reticulum Lumen | Melanosome

MKLSLVAAMLLLLSAARAEEEDKKEDVGTVVGIDLGTTYSCVGVFKNGRVEIIANDQGNRITPSYVAFTPEGERLIGDAAKNQLTSNPENTVFDAKRLIGRTWNDPSVQQDIKFLPFKVVEKKTKPYIQVDIGGGQTKTFAPEEISAMVLTKMKETAEAYLGKKVTHAVVTVPAYFNDAQRQATKDAGTIAGLNVMRIINEPTAAAIAYGLDKREGEKNILVFDLGGGTFDVSLLTIDNGVFEVVATNGDTHLGGEDFDQRVMEHFIKLYKKKTGKDVRKDNRAVQKLRREVEKAKRALSSQHQARIEIESFYEGEDFSETLTRAKFEELNMDLFRSTMKPVQKVLEDSDLKKSDIDEIVLVGGSTRIPKIQQLVKEFFNGKEPSRGINPDEAVAYGAAVQAGVLSGDQDTGDLVLLDVCPLTLGIETVGGVMTKLIPRNTVVPTKKSQIFSTASDNQPTVTIKVYEGERPLTKDNHLLGTFDLTGIPPAPRGVPQIEVTFEIDVNGILRVTAEDKGTGNKNKITITNDQNRLTPEEIERMVNDAEKFAEEDKKLKERIDTRNELESYAYSLKNQIGDKEKLGGKLSSEDKETMEKAVEEKIEWLESHQDADIEDFKAKKKELEEIVQPIISKLYGSAGPPPTGEEDTAEKDEL