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SGN-2FF

CAT: 0804-HY-107366-02Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-107366-02Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SGN-2FF is a potent and orally active inhibitor of fucosylation, directly inhibits fucosyltransferase activity. SGN-2FF possesses antitumor activity[1].
CAS Number
2089647-47-0
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
Glycosyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/SGN-2FF.html
Purity
98.0
Solubility
DMSO : 50 mg/mL (ultrasonic) |H2O : 36.67 mg/mL (ultrasonic)
Smiles
F[C@H]1[C@@H]([C@@H]([C@H](C)OC1O)O)O
Molecular Formula
C6H11FO4
Molecular Weight
166.15
Precautions
H315, H319, H320
References & Citations
[1]Stephen C. Alley, et al. Abstract DDT02-02: SGN-2FF: A novel small molecule inhibitor of fucosylation with preclinical antitumor activity through multiple immune mechanisms. Cancer Res 2017;77 (13 Suppl) .
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1

Chemical Information

GlyTouCan:G21349BB
CAS Number2089647-47-0
PubChem CID44544736
IUPAC Name(3S,4R,5S,6S)-3-fluoro-6-methyloxane-2,4,5-triol
Molecular FormulaC6H11FO4
Molecular Weight166.15
XLogP-1.1
Topological Polar Surface Area69.9
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count0
Heavy Atom Count11
Formal Charge0
Complexity143
SMILES
C[C@H]1[C@H]([C@H]([C@@H](C(O1)O)F)O)O
InChI
InChI=1S/C6H11FO4/c1-2-4(8)5(9)3(7)6(10)11-2/h2-6,8-10H,1H3/t2-,3-,4+,5-,6?/m0/s1
InChIKey
IRKXGKIPOMIQOD-ZZWDRFIYSA-N
Chemical Structure
2D Structure
2D structure of GlyTouCan:G21349BB
CAS: 2089647-47-0
CID: 44544736
Formula: C6H11FO4
MW: 166.15
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight166.15
XLogP3-1.1
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count0
Exact Mass166.06413699
Monoisotopic Mass166.06413699
Topological Polar Surface Area69.9 Ų
Heavy Atom Count11
Formal Charge0
Complexity143
Isotope Atom Count0
Defined Atom Stereocenter Count4
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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