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Tolinapant

CAT: 0804-HY-109565-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-109565-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Tolinapant (ASTX660) is an orally bioavailable dual antagonist of cellular inhibitor of apoptosis protein (cIAP) and X-linked inhibitor of apoptosis protein (XIAP) .
CAS Number
1799328-86-1
Product Name Alternative
ASTX660
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; IAP
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tolinapant.html
Purity
99.81
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C[C@H]1N(C[C@@H]2N(CC(N3CC(C)(C)C4=NC(CO)=C(CC5=CC=C(F)C=C5)C=C43)=O)C[C@@H](C)NC2)CCOC1
Molecular Formula
C30H42FN5O3
Molecular Weight
539.68
Precautions
H302, H315, H319, H335
References & Citations
[1]Tomoko Smyth, et al. Abstract 1287: The dual IAP antagonist, ASTX660, increases the anti-tumor activity of NSC 125973 in preclinical models of triple-negative breast cancer in vivo. Cancer Res 2016;76 (14 Suppl) .
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2

Alternative Products

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GTR19242424-01Tolinapant dihydrochloride
C13586-10mM/1mLTolinapant (ASTX660)
A16996-50Tolinapant (ASTX-660) 50mg
A16996-100Tolinapant (ASTX-660) 100mg
A16996-25Tolinapant (ASTX-660) 25mg
A16996-10Tolinapant (ASTX-660) 10mg
A16996-10mM-DTolinapant (ASTX-660) 10mM * 1mL in DMSO

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