P53 Antibody: APC

CAT: 0400-SPC-682D-APCSize: 100 µgDry Ice: NoHazardous: No
CAT#:0400-SPC-682D-APCSize:100 µg
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Background
P53 (tumor protein 53) is a transcription factor best known for its role in tumor suppression, but it also plays a critical role in neuronal survival, DNA repair, and apoptosis. Often referred to as the “guardian of the genome, ” p53 maintains genomic stability by regulating cell cycle checkpoints and initiating cell death in response to DNA damage. In the brain, p53 is activated by oxidative stress, excitotoxicity, and mitochondrial dysfunction—key features of neurodegenerative diseases. Overactivation of p53 can lead to excessive neuronal apoptosis, contributing to the progression of Alzheimer’s, Parkinson’s, and Huntington’s disease. Targeting p53 signaling pathways offers a promising strategy to modulate neuronal death and enhance neuroprotection in degenerative conditions.
Description
Rabbit Anti-Human p53 Polyclona
CAS Number
9007-83-4
Specifications
Predicted molecular weight at ~43.7kDa. Observed bands at ~53kDa.
Product Name Alternative
TP53, Tumor Protein 53, BCC7, LFS1, TRP53, p53 tumor suppressor
UNSPSC
12352203
UN Code
Non-hazardous
Hazard Statement
Non-hazardous
Gene ID
7157
Swiss Prot
P04637
Accession Number
NP_000537.3
Cellular Locus
Cytoplasm | Nucleus | PML body | Endoplasmic Reticulum | Mitochondrion matrix
Host
Rabbit
Species Reactivity
Human
Immunogen
Synthetic peptide from the C-terminal of human tumor protein p53.
Target
p53
Clonality
Polyclonal
Conjugation
APC
Type
Polyclonal
Applications
WB | ICC/IF
Validated Applications
IHC, ICC/IF
Field of Research
Cancer | Cell Cycle | p53 Pathway | Cancer | Tumor suppressors | Apoptosis | Cell Signaling | Epigenetics and Nuclear Signaling | DNA/RNA | DNA Damage and Repair
Purification
Peptide Affinity Purified
Detection Range
A 1:1000 dilution of SPC-682 was sufficient for detection of p53 on HeLa cell lysates using Goat anti-rabbit IgG:HRP as the secondary antibody.
Concentration
1 mg/ml
Dilution
WB (1:1000) ; ICC/IF (1:100) ; optimal dilutions for assays should be determined by the user.
Weight
0.1
Buffer
95.46mM Phosphate, 2.48mM MES and 2mM EDTA
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Georescu C.V., Saftoiu A., Georgescu C.C., Ciurea R. and Ciurea T. (2007) J Gastrointestin Liver Dis. 16 (2) : 133-9. 2. Strachan T., et al. (1999) Human Molecular Genetics 2. Ch. 18: Cancer Genetics. 3. Hansen J.E., et al. (2007) Cancer Research 67: 1769-1774. 4. Di Cesare E., et al. (2001) Ann Clin Lab Sci 31: 253-8. 5. Akere A., Otegbayo J.A. (2007) Singapore Med J. 48 (1) : 41-4.
Shipping Conditions
Blue Ice or 4ºC
Storage Conditions
Conjugated antibodies should be stored according to the product label
Specificity
Predicted molecular weight at ~43.7kDa. Observed bands at ~53kDa.
Species
Human
Location
Cytoplasm | Nucleus | PML body | Endoplasmic Reticulum | Mitochondrion matrix
Immunogen Species
Human

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