Perindoprilat

• Description :

  Perindoprilat (S 9780) is an angiotensin-converting enzyme (ACE) inhibitor with the IC50 value ranging from 1.5 to 3.2 nM. Perindoprilat can be used in hypertension research[1][2].

• CAS Number :

  [95153-31-4]

• Product Name Alternative :

  S 9780

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H312, H332

• Target :

  Angiotensin-converting Enzyme (ACE)

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/perindoprilat.html

• Purity :

  99.60

• Solubility :

  DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 175 mg/mL (ultrasonic)

• Smiles :

  O=C([C@H]1N(C([C@@H](N[C@H](C(O)=O)CCC)C)=O)[C@@]2([H])CCCC[C@@]2([H])C1)O

• Molecular Formula :

  C17H28N2O5

• Molecular Weight :

  340.41

• Precautions :

  H302, H312, H332

• References & Citations :

  [1]Perindopril. Expert Opin Pharmacother. 2006 Jan;7 (1) :63-71.|[2]Angiotensin-converting enzyme (ACE) inhibitors have different selectivity for bradykinin binding sites of human somatic ACE. Eur J Pharmacol. 2007 Dec 22;577 (1-3) :1-6.|[3]Izabella Z A Pawluczyk, et al. The role of bradykinin in the antifibrotic actions of perindoprilat on human mesangial cells. Kidney Int. 2004 Apr;65 (4) :1240-51.|[4]X-Z Wang, et al. Perindopril inhibits myocardial apoptosis in mice with acute myocardial infarction through TLR4/NF-κB pathway. Eur Rev Med Pharmacol Sci. 2019 Aug;23 (15) :6672-6682.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched