Perindoprilat

CAT: 0804-HY-B1433-01Size: 10 mM - 1 mLDry Ice: NoHazardous: No
CAT#:0804-HY-B1433-01Size:10 mM - 1 mL
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Description
Perindoprilat (S 9780) is an angiotensin-converting enzyme (ACE) inhibitor with the IC50 value ranging from 1.5 to 3.2 nM. Perindoprilat can be used in hypertension research[1][2].
CAS Number
[95153-31-4]
Product Name Alternative
S 9780
UNSPSC
12352005
Hazard Statement
H302, H312, H332
Target
Angiotensin-converting Enzyme (ACE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/perindoprilat.html
Purity
99.60
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 175 mg/mL (ultrasonic)
Smiles
O=C([C@H]1N(C([C@@H](N[C@H](C(O)=O)CCC)C)=O)[C@@]2([H])CCCC[C@@]2([H])C1)O
Molecular Formula
C17H28N2O5
Molecular Weight
340.41
Precautions
H302, H312, H332
References & Citations
[1]Perindopril. Expert Opin Pharmacother. 2006 Jan;7 (1) :63-71.|[2]Angiotensin-converting enzyme (ACE) inhibitors have different selectivity for bradykinin binding sites of human somatic ACE. Eur J Pharmacol. 2007 Dec 22;577 (1-3) :1-6.|[3]Izabella Z A Pawluczyk, et al. The role of bradykinin in the antifibrotic actions of perindoprilat on human mesangial cells. Kidney Int. 2004 Apr;65 (4) :1240-51.|[4]X-Z Wang, et al. Perindopril inhibits myocardial apoptosis in mice with acute myocardial infarction through TLR4/NF-κB pathway. Eur Rev Med Pharmacol Sci. 2019 Aug;23 (15) :6672-6682.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
Launched

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