Perindopril

CAT: 0804-HY-B0130-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0804-HY-B0130-01Size:25 mg
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Description
Perindopril (S-9490) is an orally available, long-acting angiotensin-converting enzyme (ACE) inhibitor. Perindopril inhibits inflammatory cell influx and intimal thickening, preserving elastin on the inside of the aorta. Perindopril effectively inhibits experimental abdominal aortic aneurysm (AAA) formation in a rat model and reduces pulmonary vasoconstriction in rats with pulmonary hypertension[1][2][3][4].
CAS Number
[82834-16-0]
Product Name Alternative
S-9490
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Angiotensin-converting Enzyme (ACE) ; NF-κB; Sirtuin; STAT
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; JAK/STAT Signaling; Metabolic Enzyme/Protease; NF-κB; Stem Cell/Wnt
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer; Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Perindopril.html
Purity
99.85
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic; warming; heat to 80°C)
Smiles
O=C([C@H]1N(C([C@@H](N[C@H](C(OCC)=O)CCC)C)=O)[C@@]2([H])CCCC[C@@]2([H])C1)O
Molecular Formula
C19H32N2O5
Molecular Weight
368.47
Precautions
H302, H315, H319, H335
References & Citations
[1]Bhat S A, et al. Angiotensin receptor blockade modulates NFκB and STAT3 signaling and inhibits glial activation and neuroinflammation better than angiotensin-converting enzyme inhibition [J]. Molecular neurobiology, 2016, 53: 6950-6967.|[2]Wei X, et al. Combination of perindopril erbumine and huangqi-danshen decoction protects against chronic kidney disease via sirtuin3/mitochondrial dynamics pathway [J]. Evidence-Based Complementary and Alternative Medicine, 2022, 2022.|[3]Afonso T, et al. Pharmacodynamic evaluation of 4 angiotensin‐converting enzyme inhibitors in healthy adult horses [J]. Journal of veterinary internal medicine, 2013, 27 (5) : 1185-1192.|[4]Thybo N K, et al. Dose-dependent effects of perindopril on blood pressure and small-artery structure [J]. Hypertension, 1994, 23 (5) : 659-666.|[5]Jeffery TK, et al. Perindopril, an angiotensin converting enzyme inhibitor, in pulmonary hypertensive rats: comparative effects on pulmonary vascular structure and function. Br J Pharmacol. 1999 Dec;128 (7) :1407-18.|[6]Xiong F, et al. Inhibition of AAA in a rat model by treatment with ACEI perindopril. J Surg Res. 2014 Jun 1;189 (1) :166-73.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
SIRT3; STAT3
Citation 01
Biomed Pharmacother. 2023 Apr:160:114370.|Phytomedicine. 2024 Oct 28:135:156187.|Biosci Rep. 2021 Oct 29;41 (10) :BSR20211598.|Br J Pharmacol. 2021 Mar;178 (5) :1164-1181.|Evid Based Complement Alternat Med. 2022 May 21;2022:5812105.|Stem Cell Res Ther. 2024 Oct 23;15 (1) :375.

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