Penicillic acid

• Description:

  Penicillic acid is a polyketide mycotoxin produced by several species of Aspergillus and Penicillium. Penicillic acid exhibits cytotoxicity in rat alveolar macrophages (AM) in vitro. Penicillic acid inhibits Fas ligand-induced apoptosis by blocking self-processing of caspase-8[1][2].

• UNSPSC:

  12352211

• Hazard Statement:

  H302, H312, H332

• Target:

  Antibiotic; Apoptosis; Bacterial; Caspase

• Type:

  Reference compound

• Related Pathways:

  Anti-infection; Apoptosis

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer; Infection

• Assay Protocol:

  https://www.medchemexpress.com/penicillic-acid.html

• Purity:

  99.83

• Solubility:

  DMSO : 100 mg/mL (ultrasonic) |H2O : 25 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  C=C (C) C (/C (OC) =C/C (O) =O) =O

• Molecular Formula:

  C8H10O4

• Molecular Weight:

  170.16

• Precautions:

  H302, H312, H332

• References & Citations:

  [1]Sorenson WG, et al. Toxicity of penicillic acid for rat alveolar macrophages in vitro. Environ Res. 1986 Dec;41 (2) :505-13.|[2]Bando M, et al. The mycotoxin penicillic acid inhibits Fas ligand-induced apoptosis by blocking self-processing of caspase-8 in death-inducing signaling complex. J Biol Chem. 2003 Feb 21;278 (8) :5786-93.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, sealed storage, away from moisture)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  90-65-3