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Penicillic acid

CAT: 0804-HY-N6777-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N6777-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Penicillic acid is a polyketide mycotoxin produced by several species of Aspergillus and Penicillium. Penicillic acid exhibits cytotoxicity in rat alveolar macrophages (AM) in vitro. Penicillic acid inhibits Fas ligand-induced apoptosis by blocking self-processing of caspase-8[1][2].
CAS Number
90-65-3
UNSPSC
12352211
Hazard Statement
H302, H312, H332
Target
Antibiotic; Apoptosis; Bacterial; Caspase
Type
Reference compound
Related Pathways
Anti-infection; Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/penicillic-acid.html
Purity
99.83
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 25 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
C=C(C)C(/C(OC)=C/C(O)=O)=O
Molecular Formula
C8H10O4
Molecular Weight
170.16
Precautions
H302, H312, H332
References & Citations
[1]Sorenson WG, et al. Toxicity of penicillic acid for rat alveolar macrophages in vitro. Environ Res. 1986 Dec;41 (2) :505-13.|[2]Bando M, et al. The mycotoxin penicillic acid inhibits Fas ligand-induced apoptosis by blocking self-processing of caspase-8 in death-inducing signaling complex. J Biol Chem. 2003 Feb 21;278 (8) :5786-93.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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