Asymmetric dimethylarginine-d7 (hydrochloride hydrate)

• UNSPSC Description:

  Asymmetric dimethylarginine-d7 (hydrochloride hydrate) is the deuterium labeled Asymmetric dimethylarginine. Asymmetric dimethylarginine is an endogenous inhibitor of nitric oxide synthase (NOS), and functions as a marker of endothelial dysfunction in a num

• Target Antigen:

  Endogenous Metabolite; Isotope-Labeled Compounds; NO Synthase

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  Immunology/Inflammation;Metabolic Enzyme/Protease;Others

• Field of Research:

  Cardiovascular Disease; Cancer

• Assay Protocol:

  https://www.medchemexpress.com/asymmetric-dimethylarginine-d7-hydrochloride-hydrate.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CN(C)C(NC([2H])([2H])C([2H])([2H])C([2H])([2H])C(N)([2H])C(O)=O)=N.Cl.[xH2O]

• References & Citations:

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]Hudson CL, et al. The cardiovascular risk marker asymmetric dimethylarginine is elevated in asymptomatic, untreated HIV-1 infection and correlates with markers of immune activation and disease progression. Ann Clin Biochem. 2014 Sep;51(Pt 5):568-75.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported