Products for Research Use Only
RegisterLogin

Dicyclomine-d4

CAT: 0804-HY-B1339ASSize: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-B1339ASSize:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Dicyclomine-d4 is the deuterium labeled Dicyclomine[1]. Dicyclomine (Dicycloverine) is a potent and orally active muscarinic cholinergic receptors antagonist. Dicyclomine (Dicycloverine) shows high affinity for muscarinic M1 receptor subtype (Ki=5.1 nM) and M2 receptor subtype (Ki=54.6 nM) in brush-border membrane and basal plasma membranes, respectively[2]. Dicyclomine is an antispasmodic agent and relieves smooth muscle spasm of the gastrointestinal tract in vivo[3].
Product Name Alternative
Dicycloverine-d4
UNSPSC
12352211
Target
MAChR
Type
Isotope-Labeled Compounds
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Solubility
10 mM in DMSO
Smiles
O=C(C1(C2CCCCC2)CCCCC1)OC([2H])([2H])C([2H])([2H])N(CC)CC
Molecular Formula
C19H31D4NO2
Molecular Weight
313.51
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Antonella Caccamo, et al. M1 Receptors Play a Central Role in Modulating AD-like Pathology in Transgenic Mice. 2006 Mar 2;49 (5) :671-82.doi: 10.1016/j.neuron.2006.01.020. |[3]Antonella Caccamo, et al. M1 Receptors Play a Central Role in Modulating AD-like Pathology in Transgenic Mice. 2006 Mar 249 (5) :671-82.doi: 10.1016/j.neuron.2006.01.020. |[4]Susan J Bartko, et al. A Computer-Automated Touchscreen Paired-Associates Learning (PAL) Task for Mice: Impairments Following Administration of Scopolamine or Dicyclomine and Improvements Following Donepezil.Psychopharmacology (Berl) . 2011 Mar214 (2) :537-48.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

Related Products

CatalogName
HY-B1339ADicyclomine
HY-B1339-01Dicyclomine (hydrochloride)
HY-W043718-01Dicyclomine impurity 1
HY-B1339R-01Dicyclomine (hydrochloride) (Standard)
HY-W043718RDicyclomine impurity 1 (Standard)
HY-151912S-01Picolinafen-d4 (4-Fluorophenyl-d4)
HY-132468SKeto Pioglitazone-d4 (M-III-d4)
HY-151892SGlimepiride-d4 (phenylethyl-α, α, β, β-d4) (cis/trans)
HY-151910S(±) -Fluoxetine-d4 Oxalate (trifluoromethylphen-d4-oxy)
HY-W654154Dexmedetomidine-d4 L-tartrate (-d4-major)

Alternative Products

CatalogName
446732Dicyclomine-d4 Hydrochloride
AR-D01746-01Dicycloverine-d4 HCl (Dicyclomine-d4 HCl)
T60751-01Dicyclomine
A8409-5.1Dicyclomine HCl
T1460-01Dicyclomine hydrochloride
sc-211306Dicyclomine, Hydrochloride
TRC-D156820-100MGDicyclomine N-Oxide
GTR19280793-01Dicyclomine impurity 1
TRC-D229529-10MG1',2'-Dehydro Dicyclomine
AR-D01745-01Dicycloverine HCl (Dicyclomine HCl)

Popular Products