Products for Research Use Only
RegisterLogin

Dicyclomine

CAT: 0804-HY-B1339ASize: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-B1339ASize:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Dicyclomine (Dicycloverine) is a potent and orally active muscarinic cholinergic receptors antagonist. Dicyclomine (Dicycloverine) shows high affinity for muscarinic M1 receptor subtype (Ki=5.1 nM) and M2 receptor subtype (Ki=54.6 nM) in brush-border membrane and basal plasma membranes, respectively[1]. Dicyclomine is an antispasmodic agent and relieves smooth muscle spasm of the gastrointestinal tract in vivo[2].
CAS Number
77-19-0
Product Name Alternative
Dicycloverine
UNSPSC
12352211
Hazard Statement
H302
Target
MAChR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/dicyclomine.html
Purity
90.00
Solubility
10 mM in DMSO
Smiles
O=C(C1(C2CCCCC2)CCCCC1)OCCN(CC)CC
Molecular Formula
C19H35NO2
Molecular Weight
309.49
Precautions
P264-P270-P330-P501
References & Citations
[1]Antonella Caccamo, et al. M1 Receptors Play a Central Role in Modulating AD-like Pathology in Transgenic Mice. 2006 Mar 2;49 (5) :671-82.doi: 10.1016/j.neuron.2006.01.020. |[2]Antonella Caccamo, et al. M1 Receptors Play a Central Role in Modulating AD-like Pathology in Transgenic Mice. 2006 Mar 2;49 (5) :671-82.doi: 10.1016/j.neuron.2006.01.020. |[3]Susan J Bartko, et al. A Computer-Automated Touchscreen Paired-Associates Learning (PAL) Task for Mice: Impairments Following Administration of Scopolamine or Dicyclomine and Improvements Following Donepezil.Psychopharmacology (Berl) . 2011 Mar;214 (2) :537-48.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
MAChR1; mAChR2

Alternative Products

CatalogName
T60751-01Dicyclomine
A8409-5.1Dicyclomine HCl
T1460-01Dicyclomine hydrochloride
sc-211306Dicyclomine, Hydrochloride
TRC-D156820-100MGDicyclomine N-Oxide
CS-O-11346Dicyclomine-d4 Hydrochloride
GTR19280793-01Dicyclomine impurity 1
TRC-D229529-10MG1',2'-Dehydro Dicyclomine
AR-D01745-01Dicycloverine HCl (Dicyclomine HCl)
411564-011',2'-Dehydro Dicyclomine (~90%)

Popular Products